| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 |
25권 2호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Enhanced cancer chemo-immunotherapy using nano-micelled generating dissolving microneedles containing paclitaxel and TLR7/8 agonist |
| 초록 |
Efficient drug delivery with microneedle (MN) of low dose chemical therapy agent immune-modulators adjuvants-resiquimod (R848) and paclitaxel (PTX) was synergized to demonstrate anti-cancer effect and activation of antigen-presenting cells (APCs), which thereafter induce anti-cancer memory effect. Paclitaxel treatment was speculated to cause cancer cell death which should lead to production of malignant tumor-specific antigens. R848 was used as an adjuvant and was anticipated to induce activation and maturation of immune cells for eliciting anti-cancer immune response. Here, Pluronic F127 based DMNs in situ generate nano-micelles (NMCs) upon their dissolution after subcutaneous injection. The capability of concurrent delivery of two agents-loaded NMCs was researched by watching the induced secretion of pro-inflammatory cytokines which are considered for anti-cancer activity and the expression of maturation markers (CD40, CD80) which elicit a much stronger immune stimulation effect. |
| 저자 |
황위보, 임수연, 김다훤, LYU SIYAN, 박채은, 김병덕, 정지훈
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| 소속 |
성균관대 |
| 키워드 |
biomaterial; microneedle
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| E-Mail |
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