| 학회 |
한국화학공학회 |
| 학술대회 |
2019년 가을 (10/23 ~ 10/25, 대전컨벤션센터) |
| 권호 |
25권 2호, p.1498 |
| 발표분야 |
생물화공 (Biochemical Engineering) |
| 제목 |
Detection of neuroblastoma differentiation using Bi2Se3/Ag/RNA three-way junction |
| 초록 |
Cell differentiation therapy based on nanoparticle has received great attention as a promising alternative to conventional cancer treatments. In this study, nanoparticle-based biohybrid material can completely differentiate SH-SY5Y cancer cells into neurons and stop its growth in 6 days without any other treatment. Biocompatibility and plasmonic characteristics of the biohybrid material are remarkably expressed because the bismuth selenide nanoparticle (Bi2Se3 NP) is covered with silver (Bi2Se3/Ag). The RNA three-way junction structure is also designed to allow Bi2Se3/Ag to perform four functions. One part of the three-way junction is attached to the Bi2Se3/Ag, another part attached to cell-penetrating RNA with a fluorescence tag, and the other part is assigned to inhibit microRNA-17 (miR-17) and release retinoic acid (RA). The slow release of RA through the inhibition of miR-17 allows the differentiation of neurons with little apoptosis. The cell differentiation process is monitored using SERS techniques. The developed biohybrid material can be used to the manufacture of other diagnostic/therapeutic agents. |
| 저자 |
이찬용1, Mohsen Mohammadniaei2, 신민규1, 최정우1
|
| 소속 |
1서강대, 2중앙대 |
| 키워드 |
생물화학공학 |
| E-Mail |
|
| 원문파일 |
초록 보기 |
