| 초록 |
Localization capability is one of the key factors of the development of therapeutics delivery systems. Electrospinning has drawn attention mainly due to its ECM-mimicking biomimetic structure, facileness of fabrication method, and diverse techniques to modify the properties of nanofibers. Also, the electrospun scaffolds can serve as templates for substrate-mediated therapeutics delivery for localization, increasing efficacy and reducing toxicity, which are crucial factors in developing therpauetics delivery systems. Herein, the 3D compressible and elastomeric nanofibrous scaffold is presented. It can withstand pressures exerted at the implanted site and keep its macro- and micro-morphological characteristics. In conclusion, the fabrication method discussed in the current study hold great potential as gene delivering vehicles and scaffolds for regenerative medicine via combinatorial utilization of sophisticated three-dimensional nanostructures and cutting-edge gene therapeutics.
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