| 학회 | 한국공업화학회 |
| 학술대회 | 2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 | 24권 1호 |
| 발표분야 | [국제협력] 우수외국인연구자세션 |
| 제목 | In Situ Forming and Nitric Oxide-Releasing Hydrogels with Highly Antibacterial Activities for Biomedical Applications |
| 초록 | Nitric oxide (NO), an essential signaling molecule, participates in a broad range of physiological processes, such as cardiovascular homeostasis, neuronal transmission, immunomodulation, and tumor growth. Recently, NO releasing materials have emerged as potential therapies to inhibit drug-resistance bacteria without causing undesirable effects. Herein, we developed an injectable gelatin-based hydrogels (GH) to controllably release NO by incorporating the NO donor S-nitrosothiolated gelatin (GelSNO). The hydrogels were rapidly formed via HRP/H2O2-mediated crosslinking reaction. The NO release behaviors were controlled by varying the GelSNO concentration. The killing effect against both E. coli and S. aureus as well as the cytotoxicity against human dermal fibroblasts of hydrogels were also evaluated. Acknowledgement: NRF-2018R1A2B2004529 & 2019R1A6A1A11051471 |
| 저자 | Le Thi Phuong, Thai Thanh Hoang Thi, 박기동 |
| 소속 | 아주대 |
| 키워드 | Nitric oxide(NO); hydrogels; Antibacterial activity |
