| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 |
25권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Nitric oxide releasing catalytic lipid with endothelial cell derived membrane on titanium surface for the endo-vascular implantation |
| 초록 |
To develop ideal cardiovascular devices, we suggest a model of lipid bilayer derived from endothelial cells (ECs) membrane with a phospholipid containing catalytic selenium molecule generating nitric oxide (NO) with endogenous NO precursors. We inserted selenium containing molecule into membrane from ECs and coated a titanium surface with the membrane. The tethered membrane possessed endothelium-mimetic properties and successfully released NO. EC, smooth muscle cell, and macrophage exhibited a promotive, suppressive, and immunomodulatory responses, respectively. Taken together, our results not only provide understanding of the kinetics of catalytic NO-releasing membrane and cellular responses to the membrane but also highlight the versatile design for endo-vascular implantation and bio-interfacing devices. |
| 저자 |
이주로, Mamoud A. Elnaggar, Lemon Hasan, 정윤기
|
| 소속 |
한국과학기술(연) |
| 키워드 |
Endothelial cell; vascular implantation; Nitric oxide
|
| E-Mail |
|
