| 초록 |
Proper homeostasis of Cu2+ is critical for growth and development on living organisms. In particular, imbalance of intracellular Cu2+ homeostasis is associated with neurodegenerative diseases. For understanding the roles of Cu2+ in neurological systems, it is demanded to monitor the distribution of Cu2+ in a single cell, which is however largely unexplored. Here, we develop a nanowire endoscopy for measuring intracellular distribution of Cu2+ based on a quantum dot (QD)-embedded organic nanowire that allows for in-vivo, noninvasive, and high spatial resolution analysis of Cu2+ in a cell. Remarkably, a QD-embedded polycaprolactone nanowire is grown directly to a tapered optical fiber with a high coupling efficiency, which allows optical communication in a cell with an low input laser power and in a high spatial resolution. The nanowire endoscopy enables us to measure spatial distribution of Cu2+ in microdroplets. We discuss quenching kinetics as a function of Cu2+ concentration. |
