| 초록 |
Advances in photonics have stimulated significant progress in medicine with many techniques now in routine clinical use. However, the finite depth of light penetration in tissue is a serious constraint to clinical applications. Here, we developed implantable light-delivery devices using biodegradable polymers. With this light delivery system, we demonstrated photochemical tissue bonding (PTB) for wound healing with a Rose Bengal (RB) dye, achieving a full thickness (410 mm) wound closure of porcine skin. In addition, we successfully demonstrated the facilitated PTB using hyaluronic acid (HA) – RB conjugate and upconversion nanoparticle (UCNP). The UCNP emitting red and green light in the skin tissue by skin-penetrating NIR laser illumination could activate the RB dye and crosslink the collagen, inducing skin repair and deep tissue wound healing. Furthermore, a polymer hydrogel optical fiber sensor will be presented to monitor glucose concentration for diabetic diagnosis. |
