| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Preparation of Core-Shell Nanoparticles Based on Chitosan-Bovine Serum Albumin for Drug Delivery |
| 초록 |
A facile method has been developed for preparing nanoparticles with core-shell structure based on chitosan-bovine serum albumin. The method involves a heat-gelation process to produce the bovine serum albumin core and the chitosan shell. In this study, we investigated the effect of some experimental parameters on the formation of the core-shell structure and the loading condition of doxorubicin into the nanoparticles. The nanoparticles were characterized by Zeta-potential measurements and TEM to prove the formation of core-shell structure. FTIR and fluorescence spectroscopic results confirmed the encapsulation of doxorubicin in the nanoparticles. The nanoparticles were found to be stable in a wide range of pH and the size of the nanoparticles showed a pH response property. The nanoparticles exhibited a good stability under physiological conditions and can be applied as a carrier for drug delivery. |
| 저자 |
Trong D. Nguyen, Kurt E. Geckeler
|
| 소속 |
GIST Department of Materials Science and Engineering |
| 키워드 |
Nanoparticles; Doxorubicin; Delivery
|
| E-Mail |
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