| 초록 |
Photothermal therapy has been employed to selectively kill cancer cells through localized heating. To enhance the therapeutic effect of cancer treatment, chemical drugs can combine with photothermal agents. However, production of therapeutic cargo containing highly concentrated drugs and photothermal agents with high stability and biocompatibility remains challenging. Herein, we report osmotic-pressure-controlled microfluidic approach to provide monodispersed microcapsules with high concentrated-encapsulation efficiency of drugs and polydopamine nanospheres for photothermal agent. Moreover, the shell membrane is composed of phase-change-material to control the permeability with sustained and stepwise manner by heating and cooling. These thermo-responsive microcapsules can release the drug by thermal stimulus and NIR laser irradiation for multiple times. We believe that this approach for advanced therapeutic microcapsule production is promising for cancer treatments. |
