화학공학소재연구정보센터
학회 한국공업화학회
학술대회 2015년 가을 (11/04 ~ 11/06, 제주국제컨벤션센터(ICCJEJU))
권호 19권 2호
발표분야 고분자_포스터
제목 Synthesis and Characterization of Disk-shaped Particles by RAFT Polymerization
초록 Disk-shaped particles based on polycaprolactone (PCL) were synthesized using photodegradable polymethylvinylketone (PMVK) and used for drug delivery system. In this study, PCL based triblock copolymer was synthesized by RAFT polymerization and used to fabricate microsphere by emulsion-evaporation method. Disk-shaped particles were then prepared by UV-irradiation with the microsphere. In order to polymerize by RAFT method, PCL based macro-CTA (chain transfer agent) was first synthesized by reacting carboxylic acid-terminated CTA with PCL, and used for the synthesis of block copolymer with methyl vinyl ketone (MVK). The morphology of the particles before and after UV irradiation were confirmed by SEM and TEM images and the release behavior of paclitaxel, anti-cancer agent for female cancers, in disk shape particles were evaluated by HPLC. PCL based disk-shaped particles will be anticipated to enhance drug release and could find potential application for biomaterials.
저자 정일두, 김태윤
소속 부산대
키워드 RAFT; disk-shaped particles; photodegradable; PCL; PMVK
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