| 초록 |
Mitochondria is one of the cell organelle playing a critical role as ATP synthesis, cell signaling, cell apoptosis, redox homeostasis. Recently, mitochondria are noticed with new drug target, and biomarker as a disease diagnosis. Therefore, fluorescent bioprobes monitoring mitochondria will be useful for high throughput screening to discover new drugs or disease diagnosis tool. In several studies, mitochondria targeting molecules are recommended to have a cationic charge and proper hydrophobicity. But there are not presentation about quantitative hydrophobicity to target mitochondria. So we controlled the hydrophobicity of NIR chromophore, silicon rhodamine to make a mitochondria targeting bioprobe. NIR region have advantage of live cell imaging, because of low phototoxicity, high signal to background ratio. In this poster, we just control molecular hydrophobicity to targeting mitochondria. |
