| 초록 |
An efficient drug delivery system which releases drugs under near-infrared (NIR) laser irradiation was designed and proposed. A drug carrier is based on the polydopamine (PD) as one of the neurotransmitters, which was used as customized nanoreactors for synthesizing metal nanoparticles (NPs) at the desired site within the PD. Due to the special interactions between metal precursors and the PD, individual NP was selectively positioned within the PD from core to shell. By varying the reaction cycle, it was able to control the loading amount of metal NPs up to almost 95% of the PD particles, which can assist effective release of drug even by short time irradiation of laser. We expect that our system can be used for effective drug carrier capable of controlled release by a minimal stimulus. |
