| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 |
25권 2호 |
| 발표분야 |
포스터-콜로이드·계면화학 |
| 제목 |
Enhancing Skin Permeation of Nanoemulsions through Associative Polymeric Micelles-Mediated Drop-to-Skin Dipolar Interactions |
| 초록 |
This study presents a facile but useful methodology to improve the skin permeation of nanoemulsions (NEs) through associative polymeric micelle (APM)-mediated drop-to-skin dipolar interactions. Poly(ethylene oxide)-b-poly(ε-caprolactone)-b-poly(ethylene oxide) (PEO-PCL-PEO) were co-assembled with lecithin to fabricate APMs. As model drug carriers, nanoemulsions were prepared using the same amphiphile composition. Dense-suspension rheological studies revealed that when APMs co-existed with NEs, the drop-to-drop association was predominantly influenced by the PEO chain conformation surrounding the APMs; shorter PEO chains reduced the APM-mediated NE association due to weak chain conformation. The shorter PEO chains of the APMs promoted the drop-to-skin association. Therefore, APMs with short PEO chains aided the penetration of the NE into the skin. These results highlight that manipulation of the NE drop association plays a role in enhancing dermal drug delivery performance. |
| 저자 |
신경희, 성민철, 김진웅
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| 소속 |
성균관대 |
| 키워드 |
Nanoemulsion; Polymeric micelle; Skin permeation; Chain conformation; Dipolar interaction
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| E-Mail |
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