| 초록 |
Light-responsive polymeric micelles have emerged as site-specific and time-controlled systems for advanced drug delivery. Spiropyran (SP), a well-known photochromic molecule, was used to initiate the ring-opening multibranching polymerization of glycidol to afford a series of hyperbranched polyglycerols (SP-hb-PG). The micelle assembly and disassembly were induced by an external light source owing to the reversible photoisomerization of hydrophobic SP to hydrophilic merocyanine. TEM, UV/Vis spectroscopy, and DLS demonstrated the successful assembly and disassembly of micelles. In addition, the critical micelle concentration (CMC) of respective SP-hb-PGn (n = 15, 29, and 36) micelles was determined through the fluorescence analysis of pyrene with CMC values ranging from 13 – 20 mg/L. Moreover, the superior biocompatibility of the prepared SP-hb-PG was evaluated using WI-38 cells and HeLa cells, suggesting the prospective applicability of the micelles in smart drug delivery systems. |
