| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 가을 (11/04 ~ 11/06, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
19권 2호 |
| 발표분야 |
콜로이드계면화학_포스터 |
| 제목 |
Paclitaxel-loaded Lipiodol Nanoemulsions Stabilized by Polyglycerol-poly(-caprolactone) Block Copolymers |
| 초록 |
Polyglycerol-based amphiphilic copolymers have gained much attention as a novel biomaterial in the biomedical field because of the biocompatibility and facile chemical modification capability of polyglycerol. Here, we fabricate cancer-targeted theranostic polymeric nanoemulsions composed of linear polyglycerol-poly(ε-caprolactone) (PG-PCL) diblock copolymer as a polymeric shell and CT contrast agent lipiodol as a core oil. PG-PCLs are synthesized through ring-opening polymerization, and folates are conjugated to the hydroxyl moieties of polyglycerol block with 19.2 % degree of substitution. The incorporated lipiodol facilitates to encapsulate water-insoluble anticancer drug paclitaxel in the nanoemulsion due to its high solubility of paclitaxel. In vitro studies with HeLa ovarian cancer cells demonstrate excellent anti-cancer activities (LD50 ＜ 3 ng mL-1) and the applicability as a contrast agent for CT imaging. We anticipate our PG-PCL amphiphilic polymer can be widely applied to drug delivery nanocarriers for cancer-targeting of therapeutic and imaging agents. |
| 저자 |
남윤성, Le Kim Huyen Trang
|
| 소속 |
KAIST |
| 키워드 |
polyglycerol; amphiphilic copolymers; nanoemulsions; lipiodol; paclitaxel; cancer |
| E-Mail |
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