| 초록 |
Cefpodoxime Proxetil (CPD) is an orally-absorbed prodrug of cefpodoxime. Bioavailability of Cefpodoxime Proxetil (CPD) is limited by its low solubility in aqueous solution. The objective of this work is to make fine CPD particles and then enhance its bioavailability. The size of processed CPDparticleswas reduced comparedwith original particles and particle morphologywas changed uniformly like spherical type. But CPD particles were agglomerated after process. The properties such as particle size,morphology and particle size distribution areaffected by this agglomeration. The effects of process parameter such as temperature, pressure, concentration and process time on agglomeration are investigated in this research. Particles were highly agglomeratedat hightemperaturein high pressure. It is inferred that CO2 of high temperature and pressure causes thefusion of contact surface of particles, which leads to agglomeration. And the degree of agglomeration was reduced using high ratio of CO2 weight to solution weight. |
