| 초록 |
Multilayer nano films based on various materials has been studied in a wide range of biomedical application fields such as drug delivery or cell culture environments. In this study, we have developed nanoporous multilayer films to control drug release manners. Gold nanoparticles are assembled with biocompatible polymers and dissolved by post treatment. By control parameters during layer-by-layer (LbL) assembly, multilayer thickness, porosity, and distribution of nanoparticles were easily tuned. Take full advantages of nanoporous structure, anti-cancer drug: doxorubicin was successfully loaded. Control a drug release mechanism was corresponded with multilayer structure degradation rate. To confilm nanoporous structure of nanofilm, SEM, ellipsometer and profilometer were used. In summary, we established a LbL technique-based nanoporous nanofilm system that allows the continuous release of doxorubicin. |
