| 학회 | 한국화학공학회 |
| 학술대회 | 2014년 가을 (10/22 ~ 10/24, 대전 DCC) |
| 권호 | 20권 2호, p.1449 |
| 발표분야 | 분리기술 |
| 제목 | Precipitation of Inclusion Complex and Encapsulation Particles of Cetirizine by Supercritical Anti-solvent System |
| 초록 | Antihistamines are one of the important drugs to modern people suffering from allergy by natural chemical histamine. Cetirizine is a widely used antihistamine to treat allergic rhinitis. In case of cetirizine, however, it has problems about bitter taste making users feel unpleasant. Besides, its dissolution rate is too fast to last in human body for a long time. In this research, masking bitter taste of cetirizine was achieved by formation of inclusion complex between cetirizine and β-cyclodextrin. Also, to enhance dosage convenience, drug release rate of cetirizine was slowed down by preparating cetirizine coated by poly (lactide) stereocomplex which is biodegradable polymer. These processes were carried out by aerosol solvent extraction system (ASES), which is one of the supercritical anti-solvent systems, using supercritical CO2 as anti-solvent. These two kind of product showed successful results. By formation of inclusion complex, bitter taste of cetirizine was almost removed. In case of encapsulation particle, its release rate was significantly slowed down. |
| 저자 | 손원수, 윤용석, 이춘원, 이윤우 |
| 소속 | 서울대 |
| 키워드 | SAS; ASES; Cetirizine; β-cyclodextrin; Inclusion complex; Poly (lactide); Encapsulation; Drug release rate control |
| VOD | VOD 보기 |
| 원문파일 | 초록 보기 |
