| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Bi-phase alginate carriers loaded BMP-2 for proliferation of bone marrow stromal cells |
| 초록 |
Tissue engineering has greatly benefited from growth factor-based regenerative systems. The matrix-based systems for growth factor delivery for regenerating injured tissues need to stabilize the loaded signaling molecules, control their release, and also support the structural strength as a template filling the lesion site. In this study, we adopted alginate nanohydrogels containing growth factor, Bone Morphogenetic Proteins-2(BMP-2), to improve the release profile of BMP-2 from hydrogel scaffold. We prepared three kind of hydrogel systems; alginate gels with BMP-2, alginate gels with nanoparticles containing BMP-2, and alginate gels with BMP-2 and nanoparticles. Release profiles of these bi-phase alginate carriers as well as the physical properties are evaluated. The effects of release profiles of BMP-2 from bi-phase alginate carriers on the differentiation of human bone marrow stromal cells(hBMSCs) into oesteogenic cells are reported. |
| 저자 |
임현주, 오은정, 김태정, 정호윤, 최진현, 김한도
|
| 소속 |
경북대 |
| 키워드 |
alginate; BMP-2; BMSC; osteoblast; controlled release
|
| E-Mail |
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