| 학회 | 한국공업화학회 |
| 학술대회 | 2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 | 24권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Engineering versatile photochemically triggered nanoparticles for targeted tumor therapy |
| 초록 | Nanoparticle (NP)-based tumor therapy have attracted much attention due to their tunable physical/chemical characterizations and their outstanding drug loading efficiency. Despite their strengths of the systems, there are some fundamental limitations that reduced intracellular delivery and endo/lysosome escaping. To design an advanced NP-based tumor therapy, we prepared pH sensitive polymeric NPs combined with photodynamic therapy (PSNP). A versatile NP is formed by self-assembly of a photosensitizer, pH-sensitive moiety conjugated to polysaccharide as tumor targeting agent and doxorubicin. The pH responsiveness of PSNP leads to disassembly of PSNP owing to the protonation of pH-sensitive moiety, which causes DOX release. Upon light irradiation, entrapped photosensitizers controlled oxygen molecules to produce singlet oxygen (1O2). Confocal microscopy and competitive cellular uptake studies revealed receptor-mediated endocytosis and endosomal escape capability. |
| 저자 | 안민지, 이충성, 나건 |
| 소속 | 가톨릭대 |
| 키워드 | nanoparticle; photosensitizer; photodynamic therapy; doxorubicin |
