| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
In situ photocrosslinkable hyaluronic acid based surgical glue for wound closure |
| 초록 |
Hyaluronic acid (HA), a naturally occurring polysaccharide, has been widely used as a key biomaterial in a range of therapeutic applications. Its excellent biocompatibility and bio-functions related to tissue regeneration encourage the development of HA-based hydrogels to expand its applications. This study details an in situ forming surgical glue based on photocrosslinkable HA, providing tunable mechanical properties, firm tissue adhesion and high burst pressure under wet and dynamic conditions. Depending on the degree of photocrosslinkable methacrylate groups in HA polymer chains, the mechanical properties of hyaluronate methacrylate (HAMA) hydrogels prepared by UV photocrosslinking was improved. Ex vivo adhesion tests revealed that HAMA hydrogels exhibited higher shear adhesive strength compared to gelatin methacryloyl hydrogels. The high adhesive strength and burst pressure of HAMA hydrogels, under dry and wet conditions, suggests that it may have great promise as a surgical glue. |
| 저자 |
Ajeesh Chandrasekharan1, 이혜선1, 성금용1, 안선영2, 박삼대3, 임상구2, 양승윤2
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| 소속 |
1Pusan National Univ., 2부산대, 3SNvia |
| 키워드 |
photocrosslinkable polymer; surgical glue; tissue adhesive; hyaluronic acid
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| E-Mail |
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