| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
고분자합성 |
| 제목 |
Bioinspired pH- and Temperature-Responsive Injectable Adhesive Hydrogels with Polyplexes Promotes Skin Wound Healing |
| 초록 |
We developed a bioinspired pH- and temperature-responsive in situ-forming injectable hydrogel depot that could control the delivery of DNA-bearing polyplexes for versatile biomedical applications. The pH- and temperature-responsive copolymer, composed of hydrophilic poly(ethylene glycol) (PEG) and pH- and temperature-responsive poly(sulfamethazine ester urethane) (PSMEU), has been synthesized as in situ-forming injectable hydrogel. PEG-PSMEU copolymers exist as low viscous sols at high pH and room temperature (pH 8.5, 23 oC); whereas, they transform to a viscoelastic gel at the physiological condition (pH 7.4, 37 oC). Owing to the presence of urethane linkages, the PEG-PSMEU possesses excellent adhesion strength to wide range of surfaces including glass, plastic and fresh organs. The bioinspired pH- and temperature-responsive in situ-forming injectable hydrogel may be promising for biomedical applications such as controlled delivery vehicle, tissue adhesive and tissue regeneration. |
| 저자 |
Thai Minh Duy Le, Huu Thuy Trang Duong, Thavasyappan Thambi, V. H. Giang Phan, 정지훈, 이두성
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| 소속 |
Sungkyunkwan Univ. |
| 키워드 |
Injectable hydrogel; polyplex; urethane ester; DNA; tough adhesive and wound
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| E-Mail |
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