| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Dopa-conjugated alginate hydrogel glue for rapid hemorrhage control |
| 초록 |
In this study, we prepared tissue-adhesive hemostatic glue and assessed hemostatic effects on hepatic bleeding. Alginate was used as primary polymer for the fabrication hemostatic glue, oxidized for the introduction of the tissue-adhesive Schiff base forming aldehyde and then encoded with mussel-inspired dopa. In addition, PAA was selected for as an intra-structuring polymer which ensures the gel strength and allows instantaneous glue formation. Primary glue was quickly formed within 5 to 10 seconds after the mixing oxidized alginate with PAA. The degree of oxidation and the mixing ratio of OA and PAA were precisely determined based on glue formation time and gel strength. And the extend of dopa conjugation on OA was determined by the tissue adhesion force and the elasticity of the glue. Especially, elasticity of Dopa-OA glue was significantly enhanced after introduction of dopa. Functional assay of Dopa-OA glue on hepatic bleeding animal model showed much enhanced hemostatic action. |
| 저자 |
엥흐자야1, 양수근2, 김정운1, Nguyen Phuong Hong1
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| 소속 |
1인하대병원, 2인하대 |
| 키워드 |
Alginate; Hemostatic glue; Schiff base; Dopa; Tissue adhesive
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| E-Mail |
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