| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 봄 (05/10 ~ 05/12, 광주 김대중컨벤센센터(Kimdaejung Convention Center)) |
| 권호 |
21권 1호 |
| 발표분야 |
생체재료 |
| 제목 |
Dual Stimuli of β-Cyclodextrin/Paclitaxel Complexed Hyaluronic Acid for Photothermal and Chemotherapy Guided Bio-imaging system |
| 초록 |
This study explored the use of carbonized fluorescent polydopamine(FNPs-pDA) core nanoparticles decorated with Hyaluronic acid (HA) conjugated Triphenylphosphonium (TPP) and boronic acid (BA)diol-linked β-cyclodextrin(β-CD), inclusion complexed with paclitaxel (PTX). The core FNPs-pDA allows fluorescent bioimaging and photothermal cytotoxicity activities, whereas the shell of the integrated structure regulates bio-direction for delivery of PTX to the tumor site. The carbonized FNPs-pDA was cross-linked with the boronic acid groups of HA-TPP-CD-PTX to promote the formation of boronate esters for pH-mediated photothermal activity, which have shown time dependent complete PTX release along with a photothermal mediated NIR response. In vitro dual bioimaging and photothermal-chemotherapeutic activities were compared between cancer and normal cells. Lysosomal escape and live/dead cells staining confocal images highlight the promise of this system. |
| 저자 |
최청아, 박성영
|
| 소속 |
한국교통대 |
| 키워드 |
Target Delivery; Triphenylphosphonium; Hyaluronic Acid
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| E-Mail |
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