| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 봄 (04/29 ~ 05/01, BEXCO (부산)) |
| 권호 |
19권 1호 |
| 발표분야 |
(무기재료) 기능성 무기 나노입자의 합성 및 응용 |
| 제목 |
Size-dependent applications of iron oxide nanoparticles |
| 초록 |
Iron oxide nanoparticles have been developed as efficient MRI contrast agents due to their unique magnetic property and biocompatibility. Extremely small iron oxide nanoparticles (ESIONs) smaller than 5 nm exhibits very weak magnetic properties owing to spin canting effect. This characteristic of ESIONs facilitates T1-weighted MRI through suppressing T2 contrast effect. Superparamagnetic iron oxide nanoparticles (SPIONs) with sizes ranging from 5 nm to 20 nm show very stable colloidal stability and moderate T2 contrast effect. Multifunctional nanoparticles for bimodal CT and MR imaging were prepared by a sol-gel reaction of tantalum (V) ethoxide in a microemulsion containing SPIONs. Tumor-associated blood vessels and tumor microenvironments were revealed after administration of the nanoparticles using CT and MRI, respectively. Ferrimagnetic iron oxide nanoparticles (FIONs) larger than 20 nm have strong magnetization. The theoretically predicted maximum r2 relaxivity (761 mM-1s-1) of iron oxide nanoparticles was achieved via size control ranging from 20 to 30 nm. Although r2 relaxivity of larger FIONs becomes smaller, they were efficiently taken up by various cells, allowing efficient cell labeling. Their efficient cellular uptake and strong magnetic property enabled highly sensitive MR imaging of single cells and pancreatic islets after transplantation. |
| 저자 |
이노현 |
| 소속 |
국민대 |
| 키워드 |
iron oxide; nanoparticles; MRI; contrast agents
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| E-Mail |
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