| 학회 | 한국공업화학회 |
| 학술대회 | 2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 22권 2호 |
| 발표분야 | 생체재료_포스터 |
| 제목 | pH and Redox Responsive Multi-functional Microdrug Carrier Synthesis for Selective Drug Release to Tumor Microenvironments |
| 초록 | As the cancer exhibit distinguishing environments from normal cells which called tumor micro-environments (TMEs), TME can be used as a stimuli to induce controlled drug release. However, heteregenous stimuli levels at different tumor sites and progression stage, single stimuli responsive drug carrier could not effectively release the drug to TMEs. Therefore, it is demended to develop multi-stimuli responsive drug carrier. Here, we synthesized pH and redox responsive micro-drug carrier via stop flow lithography technique. When the two different monomers were randomly copolymerized, hybrod type drug carriers were synthesized which can be fully degraded only in highly reductive and acidic conditions. Furthurmore, we synthesized Janus-type microparticle which has two chemically independent compartments. Each compartment can be degraded under different tumor microenvironment. Furthermore, each compartment individually encapsulates different model drug. |
| 저자 | 김현웅1, 최대건2, 노윤호1, 심민석2, 봉기완1 |
| 소속 | 1고려대, 2인천대 |
| 키워드 | tumor microenvironment; drug carrier; stimuli responsive drug release; stop flow lithography |
