| 초록 |
To optimize and characterize gel-spun scaffolds for vascular grafts, gel-spun tubular scaffolds fabricated in different conditions using poly(L-lactide-co-ε-caprolactone) (PLCL) were analyzed in this study. Because microfibers in the scaffold were influenced by several gel spinning conditions such as gel concentration, the flow rate and the volume of PLCL gel solution. Through SEM and porosimeter, gel-spun scaffolds were analyzed morphologically. To optimize mechanical properties like tensile strength and Young’s modulus, samples were tested in both circumstantial and longitudinal direction. In addition, blood leakage testing optimized the clinical condition of gel-spun scaffolds under blood pressure environment in blood vessels. In conclusion, gel-spun scaffolds were optimized morphologically, mechanically and functionally to apply tubular grafts for vascular tissue engineering. |
