| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 봄 (04/10 ~ 04/11, 컨벤션 뷰로(대전)) |
| 권호 |
33권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
The effect of collagen/cell incorporation into elastic PLCL scaffold |
| 초록 |
One of the challenges in the tissue engineering of tubular tissues and organs is the efficient seeding of porous scaffods in a short period of time, without affecting cell viability. Recently, poly(L-lactide-co-ε-caprolactone) (PLCL) copolymers have been applied as a biomaterial for vascular graft due to the high elastic property. However, these extruded PLCL scaffolds caused a few problems to be improved in respect of not only the cell seeding efficiency and cell in-growth. This study was focused on a collagen/smooth muscle cells mixture seeding method to improve cell adhesion and proliferation in tubular porous scaffolds for vascular grafts application. Cell adhesion and proliferation efficiency increased in collagen/SMCs incorporating PLCL scaffolds as compared with PLCL scaffolds in which only SMCs were seeded. In particular, cell proliferation and elastin contents were the highest in a PLCL scaffold with 50~100 μm pore size than any other scaffolds used in this experiment. |
| 저자 |
박인수1, 김상헌1, 김영하2, 김익환3, 김수현1
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| 소속 |
1한국과학기술(연), 2광주과학기술(연), 3고려대 |
| 키워드 |
smooth muscle cells; biodegradable elastic polymer; scaffold; collagen extracellular matrix; vascular tissue engineering
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| E-Mail |
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