| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 봄 (04/10 ~ 04/11, 컨벤션 뷰로(대전)) |
| 권호 |
33권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Characterization on tubular double-layered PLCL scaffolds for vascular tissue engineering & in vivo canine study |
| 초록 |
Double-layered scaffolds with fibrous and inner porous layer were characterized regarding mechanical testing and porosity, morphology and blood leakage testing, 2D platelet adhesion testing. In order to study fibrous structure by polymer solution spinning, PLCL gel-spining method was used. Fibrous scaffolds were fabricated following randomized test conditions by changing several main factors of PLCL solution. Double-layered scaffolds were fabricated in the two steps using salt-leaching and PLCL gel-like solution spinning. The morphology of pores and their networks varied with the salt weight ratio and humidity. According to coating of collagen and fibronectin, platelet adhesion capability was analyzed by SEM. On the basis of this study, a novel machinery device controlling fabrication conditions easily can be applied to develop various tubular scaffold for vascular tissue engineering. Their in vivo studies were showed patency after 24weeks and there is no thrombosis. |
| 저자 |
김상훈1, 김상헌1, 정은나1, 김동익2, 김수현1
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| 소속 |
1한국과학기술(연), 2성균관대 |
| 키워드 |
Vascular tissue engineering; poly(L-lactide-co-ε-caprolactone); gel spinning; double-layered scaffold
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| E-Mail |
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