| 초록 |
The fabrication and design of submicron- to nanoscale structural architectures, which geometrically or topologically mimics the native state of extracellular matrix (ECM), have received much attention in tissue engineering. Microstereolithography: Photofabrication of a precision macro-shaping and microarchitecturing of device or scaffold designs, and surface architecture is feasible for biocompatible designs and advanced medical procedures. In this study, advanced and more precisely designed microarchitectures using trimethylene carbonate-based liquid oligomers were fabricated using a custom-designed stereolithographic apparatus (SLA). Electrospinning: Electrospinning is a fiber spinning technique driven by a high-voltage electrostatic field using a polymeric solution or liquid that produces polymer fibers with diameters ranging from several micrometers down to 100 nm or less. A biochemically and functionally designed poly(L-lactide-co-ε-caprolactone) (PLCL)-based nanofabric structure, which has elastomeric properties, biodegradability, and cell adhesion and anticoagulation activity, may enable the engineering of bioactive and bioinducible vascular tissues. To this end, co-electrospun PLCL nanofabric scaffolds incorporating type I collagen or heparin were generated and evaluated. |
