| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Preparation and Characterization of Chitosan-combined PLGA nanoparticle for Oral delivery |
| 초록 |
The amphipathic PLGA has been approved to FDA for human therapy because of its excellent biocompatibility and biodegradability. It is widely used as a drug delivery system of anti cancer drugs by forming micelles through amphipathic PLGA. However, PLGA nanoparticle in oral delivery system has many problem including unstable particle and inefficient absorption in intestinal mucosa. To overcome these obstacle, chitosan was coated to PLGA nanoparticle, which may lead to enhanced bioavailability. Chitosan-coated PLGA nanoparticle (CPN) was prepared by w/o/w emulsion method. Its chemical structure was analyzed by 1H-NMR and FT-IR. In addition, its particle size and zeta potential were measured by DLS. Moreover, morphological property of CPN was observed by TEM. The thermal analysis of CPN was confirmed by TGA and DSC. Besides, cytotoxicity of CPN were assessed by MTT assay. These results suggest that CPN is superb drug carrier in oral delivery system. |
| 저자 |
유수경1, 김준수1, 정경원2, 김태훈3, 심왕근1, 나재운1
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| 소속 |
1순천대, 2조선이공대, 3CGBIO |
| 키워드 |
Chitosan; PLGA; Nanoparticle; durg delivery
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| E-Mail |
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