| 학회 |
한국고분자학회 |
| 학술대회 |
2006년 봄 (04/06 ~ 04/07, 일산킨텍스) |
| 권호 |
31권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Protein Delivery System Based on Biodegradable Thermo-reversible MPEG-PCL Diblock Copolymer Hydrogels. |
| 초록 |
As a number of therapeutic protein drugs became available, the importance for suitable release systems using biodegradable polymers has been an spright field of research for biomedical applications. Recently, PEG-based diblock and triblock polyester copolymers were studied as injectable drug delivery system. we synthesized the diblock copolymer consisting of methoxy polyethylene glycol and ε-caprolactone by ring opening polymerization. The concentrated PBS solution of MPEG-PCL diblock copolymers changed from sol to gel phase as the temperature increased. we fabricated 20 wt% PBS solutions loading 0.1 % FITC-BSA, dextran, and insulin for investigating protein release in vitro. In vivo experiments were carried out in SD rat. In conclusion, aqueous-based hydrogels of MPEG-PCL diblock copolymers demonstrated the controlled release of model protein drugs according as polymer concentration and drug loading amounts. Acknowledgement : this study was supported by KMOICE (N11-A08-1402-05-1-3) |
| 저자 |
김유한1, 현훈2, 김문석3, 양성윤1, 강길선2, 이해방3
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| 소속 |
1충남대, 2전북대, 3한국화학(연) |
| 키워드 |
MPEG-PCL diblock copolymer; Hydrogels; protein drug
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| E-Mail |
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