| 초록 |
Introduction: Here we developed bioactive self-assembling peptide nanofiber hydrogel (RADA-SP) which could recruit mesenchymal stem cells. By applying these bioactive peptides on ischemic hind limb models, the abilities of recruiting mesenchymal stem cells and therapeutic effects were evaluated. Materials and Methods: Limb ischemia was produced in ~20g athymic mice and 1% (wt/vol) peptides were injected into ischemic sites. The tissues were harvested 1, 3, 7 days after injection for histological analysis. Results: In RADA-SP group, it was shown that many mesenchymal stem cells were recruited into injected sites compared to other groups. After 7 days, SP of this group was most effectively remained in the injected region. In Masson’s trichrome staining, injection of RADA-SP could prevent fibrosis. Conclusion: In conclusion, RADA-SP is effective to recruit mesenchymal stem cells and that leads to protect limb ischemia. |
