| 학회 | 한국화학공학회 |
| 학술대회 | 2002년 봄 (04/26 ~ 04/27, 강원대학교) |
| 권호 | 8권 1호, p.2145 |
| 발표분야 | 재료 |
| 제목 | 표적지향 약물 전달 시스템을 위한 Fe3O4를 캡슐화한 PCL 나노입자의 제조 및 특성 |
| 초록 | Magnetic polymer particles have been of interest since they exhibit wide application in the fields of gene manipulation, immunoassay, cell isolation, enzyme immobilization, targeted delivery of drugs, DNA separation, and so on.Magnetic drug targeting should be safe and effective, i.e. particles capable of carrying the desired and releasing drug at a controlled rate. Since magnetic colloidal particles could in principle be a suitable vehicle their external-field responsiveness. In addition, nanoparticle encapsulation has been proven useful for reducing the toxicity of certain drugs. Nanoparticles, like other colloidal carriers extended for drug delivery, after intravenous administration, are normally retained mainly by the reticuloendothelial system. In the present work, nano-sized poly ε-caprolactone (PCL) particles, widely used as biodegradable polymeric carrier containing magnetite were prepared employing emulsification-diffusion method. This study focused on the development of the encapsulation process utilizing ethyl acetate as a dispersed solvent. The key factors which affected the characteristics of magnetic PCL particles such as their morphology, size distribution was investigated. Finally magnetic hysteresis of magnetic PCL particles was investigated. |
| 저자 | 김경연, 박성배 |
| 소속 | 연세대 |
| 키워드 | magnetite; poly ε-caprolactone; encapsulation |
| 원문파일 | 초록 보기 |
