| 초록 |
Biodegradable polymeric nanoparticles have been extensively studied as a drug delivery system for several decades. In this study, we prepared a poly(ethylene glycol)-poly(phenylalanine)-poly(D,L-lactic acid) triblock copolymer by ring opening polymerization of N-carboxyanhydride of phenylalanine and lactide. Nanoparticles were obtained by a surfactant-free emulsion-solvent evaporation method from the triblock copolymer, where the poly(ethylene glycol) chains formed hydrophilic barriers and the poly(phenylalanine)-poly(D,L-lactic acid) blocks formed a hydrophobic core. We presumed that poly(phenylalanine) blocks had a strong interaction with a model drug, 1-aminopyrene to increase the loading efficiency and also stabilized the particle structure via the interaction between the chains. The release behavior of the particles was investigated. |
