| 학회 | 한국화학공학회 |
| 학술대회 | 2008년 가을 (10/23 ~ 10/24, 부산 BEXCO) |
| 권호 | 14권 2호, p.2532 |
| 발표분야 | 공정시스템 |
| 제목 | A Database for Finding Enzyme Candidates to Synthesize a Non-natural Product |
| 초록 | To synthesize a non-natural product in a metabolic network, we have to predict an enzyme which catalyzes a novel reaction. Since a biological reaction occurs when substrates are attached to an enzyme, the suitability of binding site and reaction type is important factor to determine whether an enzyme would catalyzes a reaction or not. Thus the similarity in terms of binding site and reaction type between the original reaction and the novel one should be defined and analyzed acceptably. If two reactions are similar, the enzyme catalyzing the original reaction is considered to be able to catalyze the novel reaction as well. We have constructed a database for binding sites and reaction types so as to find similar reactions which exist in nature to a novel reaction. Acknowledgement This work was supported by the Korean Systems Biology Program from the Ministry of Education, Science and Technology through the Korea Science and Engineering Foundation (No. M10309020000-03B5002-00000), the Center for Ultramicrochemical Process Systems sponsored by KOSEF and BK21 project. |
| 저자 | 조아연, 윤홍석, 이상엽, 박선원 |
| 소속 | 한국과학기술원 |
| 키워드 | systems biology; metabolic engineering; synthetic biology |
| 원문파일 | 초록 보기 |
