| 초록 |
Tissue adhesions are well known postsurgical complications, including patient's pain, functional obstruction, and difficult reoperative surgery. In order to reduce tissue adhesion formation, physical barriers to isolate the traumatized tissue were commonly used. In this study, we prepared an alginate film to estimate its potential use as an adhesion barrier. We expected that the non-crosslinked alginate film can have good anti-tissue adhesion property, owing to its good mucoadhesiveness with injury site (inhibition of film migration without suturing) and low tissue affinity of slowly solubilized alginate in the body (prevention of tissue adhesion). The in vivo animal study using a rat model was carried out to evaluate the anti-tissue adhesion effect of the prepared alginate films. The anti-tissue adhesion effect of the non-crosslinked alginate film was compared with that of crosslinked alginate film, alginate solution, and commercialized anti-adhesion membrane (InterceedTM). |
