| 초록 |
Large bone defects caused by fraction, tumor resection, and congenital deformity are a major challenge for reconstructive surgeons. The use of biological bone grafts is considered as a common therapeutic treatment for the bone regeneration, however, limited availability of donor materials, additional painful procedure for the patients and risk of infection (autografts), in addition to the risk of immune responses and disease transmission (allografts) remain as significant drawbacks in the clinical field. In this study, we prepared injectable bone morphogenetic protein-2 (BMP-2)-embedded alginate/hyaluronic acid hydrogel which can allow controlled release of the BMP-2 for the effective bone regeneration. The mechanical properties, BMP-2 release profiles in terms of alginate/hyaluronic acid ratio, and the bone regeneration behaviors of the BMP-2-embedded hydrogels were investigated. |
