| 초록 |
The synthesis of polyester-polyether block copolymer has attracted great interest, because they can be used in future medical application in implantation, wound treatment, and as controlled-release drug carriers. To estimate the possibility of drug carrier, we synthesized the amphiphilic diblock cosisting of methoxy polyethylene glycol (MePEG) and biodegradable polyesters, such as poly(ε-caprolactone) (PCL), polylactides (PLA), poly(lactide-co-glycolide) (PLGA), and poly(γ-valreolactone), through the activated monomer ring-opening polymerization mechanism in the presence of catalysts and characterized the physicochemical properties of these diblock copolymers. Infrared spectroscopy was used to confirm the structure of synthesized diblock copolymers. The molecular weight distribution and the conversion of reaction components were verified by gel permeation chromatography (GPC). The molecular weight of each copolymer in CDCl3 solution were determined by 500 MHz 1H NMR and 13C NMR spectra. We could obtain the expectant molecular weight changing the molar ratio of MePEG and polyesters, and corroborate the feasibility of drug carrier because the synthesized copolymer formed micelle composed of hydrophobic block in core and hydrophilic block on outer shell when diblock copolymers place in water.
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