| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Thin nano-brushes for improving the stability of poly(D,L-lactide)-coated sirolimus-eluting stent |
| 초록 |
The stability of polymer-in-drug coating plays an important role in determining the properties of drug-eluting stents (DESs). Coating defects such as peeling and delamination are serious problems found in DESs that could lead to adverse events such as thrombosis. In this study, a thin layer of poly(L-lactide) (PLLA) brushes were introduced on the stent surface to prevent coating defects through two successive steps: (A) self-assembled monolayer and (B) ring-opening polymerization. The modified structures were confirmed by various analyses. A matrix of PLLA and sirolimus were ultrasonically coated on the control and modified stents. The drug release on the modified stent showed a sustained release profile as compared to the control counterpart. The SEM images of the coating after 5 months showed polymer coating defects from the control samples as compared to the modified stents. Therefore, the induction of the nano-brushes at the interface could be promisingly used for DESs. |
| 저자 |
타렉1, 조영진2, 정윤기1, 한동근1
|
| 소속 |
1한국과학기술(연), 2Korea Univ. of Science and Technology |
| 키워드 |
drug-eluting stent; polymer nano-brushes; delamination; sustain release
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| E-Mail |
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