| 초록 |
Sustainable positive drug release profile is obtained with PNIPAm thermosensitive polymers by modifying the surface of ordered nanoporous channels for different temperature. The overall release rate can be adjusted by changing the channel size of nanoporosity. The releasing rate of the drug (indomethacin) were demonstrated from pure PNIPAm polymer hydrogel and ordered nanoporous hybrid structure as a function of time and temperature. The results were consistent with the positive squeezing mechanism reported in the literature when the temperature is increased, the release rate peaks rapidly, followed by a very slow release process. |
