| 학회 |
한국화학공학회 |
| 학술대회 |
2003년 봄 (04/25 ~ 04/26, 순천대학교) |
| 권호 |
9권 1호, p.3 |
| 발표분야 |
고분자 |
| 제목 |
Prevention of inflammation induced by atRA-loaded microspheres with concurrent administration of dexamethasone |
| 초록 |
In this study, microspheres containing all-trans retinoic acid were subcutaneously injected into rats and dexamethasone was orally administered to prevent inflammation induced by injected atRA-loaded microspheres. Therefore, we hope that the metabolism of atRA can be suppressed due to the prevention of inflammation induced by atRA-loaded microspheres when dexamethasone is concurrently administered. Many fibroblasts around microspheres were observed at implant sites of atRA-loaded microspheres. But, dexamethasone effectively inhibited the fibroblast proliferation compared to atRA-loaded microspheres treated group alone. The atRA plasma concentration in atRA MS treated group was lower than those in co-treated group of atRA MS and dexamethasone. Therefore, we concluded that co-administration of dexamethasone could effectively prevent fibroblast proliferation and severe collagen deposition acted as obstacles of atRA systemic delivery resulting in the increase of atRA plasma concentration. |
| 저자 |
박경순1, 최용두1, 김상윤2, 김선희3, 변영로1
|
| 소속 |
1광주과학기술원 신소재공학과, 2울산대, 3성균관대 |
| 키워드 |
all-trans retinoic acid; biodegradable microsphere; inflammation; dexamethasone
|
| E-Mail |
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| VOD |
VOD 보기 |
