| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 봄 (04/09 ~ 04/10, 고려대학교) |
| 권호 | 29권 1호, p.321 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | PLGA Scaffold as Novel Drug Carriers for Protein |
| 초록 | Recently, the study of special protein release has attracted much attention for example, sustained release of active growth factors (such as EGF, NGF and BDNF etc.) are required in order to achieve desirable therapy for tissue engineering research due to the shortness of in vivo half-lives of the proteins. In this study, we reported the preparation and characterization of a novel biodegradable protein delivery device based on the PLGA scaffold. PLGA scaffold as a protein carrier prepared by a novel ice particle leaching method. Bovine serum albumin (BSA) is used as a model protein to examine the release behavior of prepared PLGA scaffold. BSA-loaded PLGA scaffolds were characterized by scanning electron microscopy (SEM) and mercury porosimetry, and the BSA release pattern was analyzed by fluorescent spectrometer. BSA-loaded PLGA scaffolds exhibited porosity above 90% medium pore size ranging from 180 to 250 ㎛. The feasibility of using the PLGA for the incorporation of BSA in a controlled-release implant form is investigated for the improvement of BSA release capability. Acknowledgement : This work was supported by grant from KMOCIE (N11-A08-1402-05-1-3) |
| 저자 | 송지희1, 장지욱2, 김문석2, 조선행2, 강길선1, 이일우3, 이해방2 |
| 소속 | 1전북대, 2한국화학(연), 3가톨릭의대 신경외과 |
| 키워드 | PLGA scaffold; ice particle leaching method; protein carrier; BSA |
