| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Effective chondrogenic differentiation of stem cell in RGD-grafted Pluronic F127 hydrogel |
| 초록 |
Thermogelling Pluronic F127 hydrogel approved by the FDA has been studied extensively for drug delivery system and tissue engineering as a biomaterial for human applications. For improving cell adhesion and biodegradability FGM-RGD was synthesized by covalent bonding of RGD peptides to F127-glycolide-4-methacryloxyethyl trimellitic anhydride (FGM), where Pluronic F127 derivatives have novel temperature-sensitive properties. These polymers were characterized by 1H-NMR, FTIR, GPC, and elemental analyzer. In the cell viability study, the optical density (OD) of cell in FGM gel was resulted in very low value. It was revealed from cell counter kit-8 (CCK-8) that the toxicity increased as the content of APS/TEMED increased, and resulted in inhibiting the cell viability of chondrocytes. In order to enhance cell viability in hydrogel, COOH group-blocking FGM and RGD-grafted FGM will be synthesized and characterized. |
| 저자 |
이혜선1, 이봉수2, 최보규1, 박귀덕2, 정병문1, 한동근2
|
| 소속 |
1KIST, 2이화여자대 |
| 키워드 |
Thermosensitives hydrogel RGD-grafted Pluronic F127; APS/TEMED; chondrogenic differentiation
|
| E-Mail |
|
