| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.465 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | The effects of crystallinity and solubility on release profile of nifedipine |
| 초록 | Among the various novel drug systems available in pharmaceutical industry , oral delivery systems hold the major part because of their obvious advantages of ease administration and better patient compliance.1 In present study, nifedipine(ND) beads were manufactured by fluidized-bed spray coating method, and used nifedipine(ND) produced by different companies. because the characters of durg would differ each companies. Crystallinity of NDs was examined by DSC and XRD. Release rates of those were increased according to the decrease of crystallinity. Also, NDs have different solubilities to dissolution media. Dissolution tests of NDs were examined in different media. NDs release rates were increased in high solubility. In conclusion, we confirmed that solubility and crystallinity of drug influenced in release profile. Acknowledgement : This work was supported by KMOCIE(10016482) Reference 1. R.K. Verma, B. Mishra and S. Garg, Osmotically controlled oral drug delivery, Drug Dev. Ind. Pharm. 26, 695,(2000) |
| 저자 | 조영호1, 전세강1, 정성찬2, 최경수1, 김문석3, 조선행3, 강길선1, 이봉2, 이해방3 |
| 소속 | 1전북대, 2부경대, 3한국화학(연) |
| 키워드 | nifedipin; stability; solubility |
