| 초록 |
A new transdermal drug delivery system having improved water absorbability and adhesion properties was invented. More particularly, this invention relates to an adhesive based transdermal drug delivery system comprising a backing film, an adhesive matrix layer containing active ingredients, and a release liner that is peelable prior to use. The matrix layer of the system is a multi-layered sandwich and comprises drug containing outer adhesive layers, adhering to the backing film and release liner respectively, between which is sandwiched an absorption enhancer layer. The adhesive layers comprise an acrylate adhesive, a mixture of high and low molecular weight polyvinylpyrrolidones, and a colloidal silica. The absorption enhancer layer comprises non-ionic surfactants, terpenes and dissolution assistants. This transdermal drug delivery system provides several desired improvements: excellent penetration of active ingredients through the skin; stable adhesion to skin wet with perspiration for extended periods of time; and no adhesive residue left on the skin when the system is detached. When applied to the skin, the system can absorb perspiration from the skin and maintain its adhesive strength. In addition, the system results in increased transdermal absorption of the active ingredient through the skin and causes reduced pain when it is removed from the skin. |
