| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 봄 (04/10 ~ 04/11, 컨벤션 뷰로(대전)) |
| 권호 |
33권 1호 |
| 발표분야 |
줄기세포 제어 고분자 |
| 제목 |
A novel cell-derived extracellular matrix (ECM) scaffold for cartilage tissue engineering |
| 초록 |
Recently, the natural extracellular matrix (ECM) scaffolds are gaining a keen attention in the tissue engineering field, because they are highly biocompatible and provide not only a physical support but also favorable environments to cells. This talk introduces a novel ECM scaffold derived from cultured chondrocytes. Porcine chondrocytes were cultured in monolayer to form a highly dense ECM network around the cell. The ECM-cell layer was then reconstructed to a highly porous 3-D ECM scaffold. The cell-derived ECM scaffold was biocompatible and showed good physicochemical properties for tissue engineering purpose. It was also highly efficient to construct hyaline-like cartilage from chondrocytes and supported well chondrogenesis of mesenchymal stem cells (MSCs). Therefore, the cell-derived ECM scaffolds could be a promising platform to construct implantable artificial cartilages from chondrocytes or stem cells, probably by providing cells with a natural cartilage-like environment. |
| 저자 |
Byung Hyune Choi1, Cheng Zhe Jin2, So Ra Park1, Byoung-Hyun Min2
|
| 소속 |
1Cell Therapy Center, 2Ajou Univ. School of Medicine |
| 키워드 |
extracellular matrix; scaffold; tissue engineering; cartilage; chondrocytes; mesenchymal stem cells
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| E-Mail |
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