| 학회 |
한국고분자학회 |
| 학술대회 |
2004년 봄 (04/09 ~ 04/10, 고려대학교) |
| 권호 |
29권 1호, p.225 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Fabrication of porous poly(lactic-co-glycolic acid) microspheres |
| 초록 |
Double emulsion solvent evaporation method has been popularly used to encapsulate protein drugs within biodegradable poly(lactic-co-glycolic acid) (PLGA) microspheres. We fabricated highly porous biodegradable polymeric microspheres by solvent evaporation technique using a polymer blend composed of water insoluble polymer (PLGA) and water soluble polymer (Pluronic F127) as a porogen. The pores are uniformly distributed and well inter-connected on the surface and within inside of resultant PLGA microspheres. These pores could be closed by the treatment of various water-miscible solvents. Gradual morphological change was observed from a pore-opened state to a pore-closed state. These open pore PLGA microspheres could be used likely for sustained delivery of bioactive macromolecules |
| 저자 |
김홍기, 박태관
|
| 소속 |
한국과학기술원 생명과학과 |
| 키워드 |
porous particle; PLGA; porogen
|
| E-Mail |
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