| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 봄 (04/10 ~ 04/11, 컨벤션 뷰로(대전)) |
| 권호 |
33권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Protophophyrin IX-containing hydrophobically modified glycol chitosan nanoparticles for effective photodynamic therapy |
| 초록 |
Photodynamic therapy is treatement using photosensitizers that generate reactive oxygen species (ROS). To increase cancer targeting and reduce photosensitizer’s toxicity, we used hydrophobically modified glycol chitosan loaded and protoporphyrin IX (PpIX-HGC), photosensitizer. photodynamic effect of PpIX-HGC was confirmed by cell apoptosis and animal test. After cells uptake PPIX-HGC, were irradiated with a 633 nm laser source (He-Ne laser). Cells were induced apoptosis. In animal test, PpIX-10wt%-HGC nanoparticles were injected via a tail vein. After 24 h post-injection, solid tumors were irradiated with a 633 nm laser source (He-Ne laser 3 mW /cm2) for 1 h. Then, we monitored the induction of necrosis or apoptosis in solid tumor of mice. |
| 저자 |
이소진1, 박경순1, 김광명1, 권익찬1, 오유경2
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| 소속 |
1한국과학기술(연), 2고려대 |
| 키워드 |
Photodynamic therapy; protoporphyrin IX; ROS
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| E-Mail |
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