| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_생물공학 |
| 제목 |
In vivo Adeno-Associated Viral (AAV) vectors screening for the Treatment of Pulmonary Arterial Hypertension |
| 초록 |
Pulmonary arterial hypertension (PAH) is a serious disease. The main pathogenesis of PAH is increase of blood pressure and pulmonary vascular resistance with structural narrowing of blood vessels due to excessive proliferation of vascular smooth muscle cells. We studied Adeno-Associated Viral (AAV) vectors, novel tools for tissue-specific gene therapy in potential applicability to PAH treatment. AAV vectors can penetrate high-density extracellular matrix because of their small size. For developing AAV vectors that have a specific tropism in the pulmonary arterial tissue, AAV serotype that is specific to pulmonary artery smooth muscle cells was selected with in vivo screening. The aerosolizer can improve efficiency of delivering AAV vectors to the lungs. Aerosolized AAV vectors with luciferase as transgenic was inhaled into the mouse respiratory tract, and we selected AAV serotypes which are specific to pulmonary artery smooth muscle cells. |
| 저자 |
김윤하, 장재형
|
| 소속 |
연세대 |
| 키워드 |
Adeno-associated virus; pulmonary artery smooth muscle cell; Aerosolizer
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| E-Mail |
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